Research Validity

Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor

Accumulating evidence indicates high risk of bias in preclinical animal research, questioning the scientific validity and reproducibility of published research findings. Systematic reviews found low rates of reporting of measures against risks of …

Data sharing in PLOS ONE: An analysis of Data Availability Statements

A number of publishers and funders, including PLOS, have recently adopted policies requiring researchers to share the data underlying their results and publications. Such policies help increase the reproducibility of the published literature, as well …

Poor statistical reporting, inadequate data presentation and spin persist despite editorial advice

The Journal of Physiology and British Journal of Pharmacology jointly published an editorial series in 2011 to improve standards in statistical reporting and data analysis. It is not known whether reporting practices changed in response to the …

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of …