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The ClinicalTrials.gov Results Database — Update and Key Issues

BACKGROUND The ClinicalTrials.gov trial registry was expanded in 2008 to include a database for reporting summary results. We summarize the structure and contents of the results database, provide an update of relevant policies, and show how the data …

The Corpus of Language Discrimination in Interaction

The Corpus of Language Discrimination in Interaction (CLDI) is an open-access, transcribed video corpus capturing real-life instances of language-based discrimination in public spaces. Compiled from citizen recordings and security footage, it …

The costs of competition in distributing scarce research funds

Research funding systems fundamentally influence how science operates. This paper aims to analyze the allocation of competitive research funding from different perspectives: How reliable are decision processes for funding? What are the economic costs …

The Costs of HARKing

Kerr ([1998]) coined the term ‘HARKing’ to refer to the practice of ‘hypothesizing after the results are known’. This questionable research practice has received increased attention in recent years because it is thought to have contributed to low …

The crisis of confidence in social psychology.

Notes that social psychologists' early enthusiasm has been replaced by serious doubts about the future of their field. Difficulties in conducting research, unfulfilled expectations about research payoffs, and outside pressures had all contributed to …

The cumulative effect of reporting and citation biases on the apparent efficacy of treatments: the case of depression

Evidence-based medicine is the cornerstone of clinical practice, but it is dependent on the quality of evidence upon which it is based. Unfortunately, up to half of all randomized controlled trials (RCTs) have never been published, and trials with …

The default bayesian test is prejudiced against small effects

When considering any statistical tool I think it is useful to answer the following two practical questions: 1. "Does it give reasonable answers in realistic circumstances?" and 2. "Does it answer a question I am interested in?" In this post I explain …

The earth is flat (p > 0.05): significance thresholds and the crisis of unreplicable research

The widespread use of ‘statistical significance’ as a license for making a claim of a scientific finding leads to considerable distortion of the scientific process (according to the American Statistical Association). We review why degrading p-values …

The earth is round (p < .05).

After 4 decades of severe criticism, the ritual of null hypothesis significance testing (mechanical dichotomous decisions around a sacred .05 criterion) still persists. This article reviews the problems with this practice, including near universal …

The Economics of Reproducibility in Preclinical Research

Low reproducibility rates within life science research undermine cumulative knowledge production and contribute to both delays and costs of therapeutic drug development. An analysis of past studies indicates that the cumulative (total) prevalence of …
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