Resources

 

We have an amazing team who curated many resources for the community.

Do p values lose their meaning in exploratory analyses? It depends how you define the familywise error rate

Several researchers have recently argued that p values lose their meaning in exploratory analyses due to an unknown inflation of the alpha level (e.g., Nosek & Lakens, 2014; Wagenmakers, 2016). For this argument to be tenable, the familywise error …

Paths in strange spaces: A comment on preregistration

This is an archived version of a blog post on preregistration. The first half of the post argues that there is not a strong justification for preregistration as a tool to solve problems with statistical inference (p-hacking); the second half argues …

Preregistration, Replication, and Nonexperimental Studies

In last month’s column, I worried about whether encouraging us to preregister our hypotheses and analysis plan before running studies would stifle discovery. I came to the conclusion that it needn’t — but that we need to guard against letting the …

Why Preregistration Makes Me Nervous

I must admit that when I first heard of the effort to get psychological scientists to preregister their studies (that is, to submit to a journal a study’s hypotheses and a plan for how the data will be analyzed before that study has been run), I had …

Equity, transparency, and accountability: Open science for the 21st century

Knowledge is essential to saving lives and improving wellbeing. The term open science has been applied to improving the transparency of knowledge generation, but open science also has the potential to address many of the problems of inequity, …

Feasibility of Emulating Clinical Trials Supporting US FDA Supplemental Indication Approvals of Drugs and Biologics

The US Food and Drug Administration (FDA) has developed a framework to use data gathered outside of clinical trials (eg, electronic health record [EHR] and insurance claims data) for evaluations of medical product safety and effectiveness. These …

Medicines and Healthcare products Regulatory Agency’s “Consultation on proposals for legislative changes for clinical trials”: a response from the Trials Methodology Research Partnership Adaptive Designs Working Group, with a focus on data sharing

In the UK, the Medicines and Healthcare products Regulatory Agency consulted on proposals “to improve and strengthen the UK clinical trials legislation to help us make the UK the best place to research and develop safe and innovative medicines”. The …

NIAID Centers of Excellence for Influenza Research and Response (CEIRR) Data Standards

The goal of the NIAID Centers of Excellence for Influenza Research and Response (CEIRR) awards is to provide the federal government, scientists, and public health personnel with information and public health tools and strategies needed to control and …

Participatory Research Approaches in Alzheimer’s Disease and Related Dementias Literature: A Scoping Review

Background and Objectives Given the increase in methodological pluralism in research on brain health, cognitive aging, and neurodegenerative diseases, this scoping review aims to provide a descriptive overview and qualitative content analysis of …

The secret to writing a great NASA proposal

Use a real NASA proposal as a roadmap and follow these tips for clearly presenting your research ideas. I’m a 100% soft money-funded research scientist primarily funded by NASA research grants. I teamed with the Jet Propulsion Laboratory (JPL) to …
JUST-OS