The methods and results of health research are documented in study protocols, full study reports (detailing all analyses), journal reports, and participant-level datasets. However, protocols, full study reports, and participant-level datasets are ā¦
Archaeology has an issue with "just-in-time" research, where insufficient attention is paid to articulating a research design before fieldwork begins. Data collection, management, and analysis approaches are under-planned and, often, evolve during ā¦
This series of lecture slides were used during the "Advanced Simulation for Health Economic Analysis" course at the University of Twente, which took place in February - May 2023.
The following Open Science topics were introduced to the course ā¦
Proponents of preregistration argue that, among other benefits, it improves the diagnosticity of statistical tests. In the strong version of this argument, preregistration does this by solving statistical problems, such as family-wise error rates. In ā¦
Public concerns about the perils associated with incomplete or delayed reporting of results from clinical trials has heightened interest in trial registries and results databases. Here we review the current status of trial registration efforts and ā¦
The scientiļ¬c endeavor is one in which the capacity to replicateļ¬ndings is a foundational tenant. It is unfortunate that therehave been a number of highly publicized cases over the pastdecade of scientists who have not practiced science with ā¦
There has been much talk of psychological science undergoing a renaissance with recent years being marked by dramatic changes in research practices and to the publishing landscape. This article briefly summarises a number of the ways in which ā¦
Background: We explore whether the number of null results in large National Heart Lung, and Blood Institute (NHLBI) funded trials has increased over time. Methods: We identified all large NHLBI supported RCTs between 1970 and 2012 evaluating drugs or ā¦
A combination of confirmation bias, hindsight bias, and pressure to publish may prompt the (unconscious) exploration of various methodological options and reporting only the ones that lead to a (statistically) significant outcome. This undisclosed ā¦
The results of many published studies across many scientific domains are not easily reproduced by independent laboratories. For example, an initiative by Bayer Healthcare to replicate 67 pre-clinical studies led to a reproducibility rate of 20-25% ā¦