About this resource

    Type of resources
    Reading
    Education level(s)
    College / Upper Division (Undergraduates), Graduate / Professional
    Primary user(s)
    Student, Teacher
    Subject area(s)
    Applied Science, Life Science, Math & Statistics, Social Science
    Language(s)
    English
    Cluster
    Pre-analysis Planning
    Last updated
    9 November 2026
    Reading

    Pre-registration of clinical trials is associated with fewer positive findings

    By Bill Gardner

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    Level College / Upper Division (Undergraduates), Graduate / Professional · For Student, Teacher · Language English

    Abstract

    Blog post by Bill Gardner (The Incidental Economist, August 2015) on a study by Robert Kaplan and Veronica Irvin of large NHLBI-funded cardiovascular trials. Of the trials published before 2000, 57% reported a significant benefit on the primary outcome, compared with 8% of those published after 2000, by which time all were prospectively registered on ClinicalTrials.gov.

    Keywords Blog · Reproducibility Crisis and Credibility Revolution