About this resource

    Type of resources
    Primary Source, Reading, Paper
    Education level(s)
    College / Upper Division (Undergraduates)
    Primary user(s)
    Student
    Subject area(s)
    Social Science
    Language(s)
    English
    Cluster
    Replication Crisis and Credibility Revolution
    Last updated
    9 November 2026
    Primary SourceReadingPaper

    RIPOSTE: A Framework for Improving the Design and Analysis of Laboratory-Based Research

    By Nicholas GD Masca, Elizabeth MA Hensor, Victoria R Cornelius, Francesca M Buffa, Helen M Marriott, James M Eales, Michael P Messenger, Amy E Anderson, Chris Boot, Catey Bunce, Robert D Goldin, Jessica Harris, Rod F Hinchliffe, Hiba Junaid, Shaun Kingston, Carmen Martin-Ruiz, Christopher P Nelson, Janet Peacock, Paul T Seed, Bethany Shinkins, Karl J Staples, Jamie Toombs, Adam KA Wright, M Dawn Teare

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    Level College / Upper Division (Undergraduates) · For Student · Language English

    Abstract

    Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contribute to this problem. The RIPOSTE (Reducing IrreProducibility in labOratory STudiEs) framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies and, therefore, to reduce irreproducibility. This framework is intended for use during the early stages of a research project, when specific questions or hypotheses are proposed. The essential points within the framework are explained and illustrated using three examples (a medical equipment test, a macrophage study and a gene expression study). Sound study design minimises the possibility of bias being introduced into experiments and leads to higher quality research with more reproducible results.

    Keywords Reproducibility Crisis and Credibility Revolution