Meta-Science

Association between trial registration and treatment effect estimates: a meta-epidemiological study

To increase transparency in research, the International Committee of Medical Journal Editors required, in 2005, prospective registration of clinical trials as a condition to publication. However, many trials remain unregistered or retrospectively …

Meta-assessment of bias in science

Numerous biases are believed to affect the scientific literature, but their actual prevalence across disciplines is unknown. To gain a comprehensive picture of the potential imprint of bias in science, we probed for the most commonly postulated …

Preregistration: the good, the bad, and the confusing

Preregistration is a tool to enhance the reliability of science that has been promoted as a normative requirement for the award of grants or the acceptance of publications. I argue that: (a) preregistration addresses an important need, (b) it offers …