A recent workshop focused on the idea that protocols for nonrandomized studies should be registered in advance of their conduct. In reviewing the workshop report and publications citing it, I note a number of unfounded assumptions and little …
What is Preregistration? When you preregister your research, you're simply specifying your research plan in advance of your study and submitting it to a registry. Preregistration separates hypothesis-generating (exploratory) from hypothesis-testing …
Study preregistration is one of several “open science” practices (e.g., open data, preprints) that researchers use to improve the transparency and rigour of their research. As more researchers adopt preregistration as a regular research practice, …
In this editorial, we define the practice of “preregistration” of research and describe its motivations, explain why we believe preregistration templates should make preregistration more effective as an intervention for improving the quality of …
In last month’s column, I worried about whether encouraging us to preregister our hypotheses and analysis plan before running studies would stifle discovery. I came to the conclusion that it needn’t — but that we need to guard against letting the …
Questionable research practices (QRPs), such as p-hacking (i.e., the inappropriate manipulation of data analysis to find statistical significance) and post hoc hypothesizing, are threats to the replicability of research findings. One key solution to …
Purpose: In the last decade, psychology and other sciences have implemented numerous reforms to improve the robustness of our research, many of which are based on increasing transparency throughout the research process. Among these reforms is the …
The purpose of this paper is to help think through the advantages and costs of rigorous pre-specification of statistical analysis plans in economics. A pre-analysis plan pre-specifies in a precise way the analysis to be run before examining the data. …
Objective To review patterns of publication of clinical trials funded by US National Institutes of Health (NIH) in peer reviewed biomedical journals indexed by Medline. Design Cross sectional analysis. Setting Clinical trials funded by NIH and …
Objectives
The ultimate goal of biomedical research is the development of new treatment options for patients. Animal models are used if questions cannot be addressed otherwise. Currently, it is widely believed that a large fraction of performed …