Research Design

Data sharing practices in collaborative human genomic research in low- and middle-income countries: A systematic review protocol

Introduction The practice of creating large databases has become increasingly common by combining research participants’ data into larger repositories. Funders now require that data sharing be considered in newly funded research project, unless there …

Getting Involved with TOP Factor

This webinar provides an overview of TOP Factor: its rationale, how it is being used, and how each of the TOP standards relate to individual scores. We also cover how to get involved with TOP Factor by inviting interested community members to suggest …

Increasing efficiency of preclinical research by group sequential designs

Despite the potential benefits of sequential designs, studies evaluating treatments or experimental manipulations in preclinical experimental biomedicine almost exclusively use classical block designs. Our aim with this article is to bring the …

Premiering pre-registration at PLOS Biology

Pre-registration promises to address some of the problems with traditional peer-review. As we publish our first Registered Report, we take stock of two years of submissions and the future possibilities of this approach.

Preregistration of animal research protocols: development and 3-year overview of preclinicaltrials.eu

Open, prospective registration of a study protocol can improve research rigour in a number of ways. Through preregistration, key features of the study’s methodology are recorded and maintained as a permanent record, enabling comparison of the …

Ten quick tips for building FAIR workflows

Research data is accumulating rapidly and with it the challenge of fully reproducible science. As a consequence, implementation of high-quality management of scientific data has become a global priority. The FAIR (Findable, Accesible, Interoperable …