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Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes

Biswanath Chattopadhyay, Kanad Baksi, Saikat Mukhopadhyay, Nitai P. Bhattacharyya

Neuroscience Letters, 2005. DOI 10.1016/j.neulet.2004.10.018

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 failed.

Replications

• Age at onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD), Arning et al. (2005). Outcome recorded: failed. In this replication study, no association was found explaining a significant amount of the variability in AO of HD thus contradicting a recent report. View paper

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