Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Miriam F. Moffatt, Michael Kabesch, Liming Liang, Anna L. Dixon, David Strachan, Simon Heath, Martin Depner, Andrea von Berg, Albrecht Bufe, Ernst Rietschel, Andrea Heinzmann, Burkard Simma, Thomas Frischer, Saffron A. G. Willis-Owen, Kenny C. C. Wong, Thomas Illig, Christian Vogelberg, Stephan K. Weiland, Erika von Mutius, Gonçalo R. Abecasis, Martin Farrall, Ivo G. Gut, G. Mark Lathrop, William O. C. Cookson

Nature, 2007. DOI 10.1038/nature06014

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 successful. The earliest on record is from 2011.

Replications

Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population, Qiu et al. (2011). BMC Medical Genetics. Outcome recorded: successful. Our replication study suggests that variants in 17q21 are significantly associated with risk of adult-onset asthma and gene expression in a Chinese Han population. Outcome read from the abstract. View paper

Cite this record

Moffatt, M. F., Kabesch, M., Liang, L., Dixon, A. L., Strachan, D., Heath, S., Depner, M., von Berg, A., Bufe, A., Rietschel, E., Heinzmann, A., Simma, B., Frischer, T., Willis-Owen, S. A. G., Wong, K. C. C., Illig, T., Vogelberg, C., Weiland, S. K., von Mutius, E., … Cookson, W. O. C. (2007). Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature, 448(7152), 470–473. https://doi.org/10.1038/nature06014

Other studies in the atlas

Failed replications · Successful replications · All browse pages