Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction
Has this study been replicated?
The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2024.
Replications
- Replication study on the role of dopamine-dependent prefrontal reactivations in human extinction memory retrieval, Andres et al. (2024). Nature Communications. Outcome recorded: mixed.
We confirm that spontaneous post-extinction vmPFC reactivations predict extinction memory retrieval. This predictive effect, however, was only observed 90 min after extinction, and was not statistically significant at 45 min as in the discovery study. In contrast to our previous study, we find no evi dence that L-DOPA administration significantly enhances retrieval and that this is mediated by enhancement of the number of vmPFC reactivations.
Outcome read from the abstract. View paper
Cite this record
Gerlicher, A. M. V., Tüscher, O., & Kalisch, R. (2018). Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction. Nature Communications, 9(1). https://doi.org/10.1038/s41467-018-06785-y
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