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Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells

Jimmy Manyanga, Vengatesh Ganapathy, Célia Bouharati, Toral Mehta, Balaji Sadhasivam, Pawan Acharya, Daniel Zhao, Lurdes Queimado

Scientific Reports, 2021. DOI 10.1038/s41598-021-81148-0

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 failed.

Replications

• Effect of electronic cigarette aerosols on cisplatin resistance in head and neck cancer cells: a collaborative replication study, Emma et al. (2026). Outcome recorded: failed. Contrary to previous findings, exposure to e-cig aerosols did not significantly modulate cisplatin sensitivity in all cell lines. IC50 values, cytotoxicity assays, and clonogenic survival rates remained similar between cells treated with e-cig aerosols and those exposed to cisplatin alone. View paper

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