Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells
Has this study been replicated?
The atlas records 1 replication of this study. Recorded outcomes: 1 failed. The earliest on record is from 2026.
Replications
- Effect of electronic cigarette aerosols on cisplatin resistance in head and neck cancer cells: a collaborative replication study, Emma et al. (2026). BMC Cancer. Outcome recorded: failed.
Contrary to previous findings, exposure to e-cig aerosols did not significantly modulate cisplatin sensitivity in all cell lines. IC50 values, cytotoxicity assays, and clonogenic survival rates remained similar between cells treated with e-cig aerosols and those exposed to cisplatin alone.
Outcome read from the abstract. View paper
Cite this record
Manyanga, J., Ganapathy, V., Bouharati, C., Mehta, T., Sadhasivam, B., Acharya, P., Zhao, D., & Queimado, L. (2021). Electronic cigarette aerosols alter the expression of cisplatin transporters and increase drug resistance in oral cancer cells. Scientific Reports, 11(1). https://doi.org/10.1038/s41598-021-81148-0
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