Distinct patterns of brain activity in young carriers of the APOE -ε4 allele
Has this study been replicated?
The atlas records 1 replication of this study. Recorded outcomes: 1 failed. The earliest on record is from 2021.
Replications
- Functional co-activation of the default mode network in APOE ε4-carriers: A replication study, Mentink et al. (2021). NeuroImage. Outcome recorded: failed.
Our primary analysis did not replicate the early findings of Filippini et al. (2009). However, compared with non-carriers, APOE ε4-carriers showed increased functional activation during the encoding of subsequently recollected items in areas related to facial recognition (p756.11). This increased functional activation was also positively associated with PRS (APOE variants included) (p647.55). Our results are supportive for none to limited genetic effects on brain structure…
Outcome read from the abstract. View paper
Cite this record
Filippini, N., MacIntosh, B. J., Hough, M. G., Goodwin, G. M., Frisoni, G. B., Smith, S. M., Matthews, P. M., Beckmann, C. F., & Mackay, C. E. (2009). Distinct patterns of brain activity in young carriers of the APOE -ε4 allele. Proceedings of the National Academy of Sciences, 106(17), 7209–7214. https://doi.org/10.1073/pnas.0811879106
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