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Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

Marina Sirota, Joel T. Dudley, Jeewon Kim, Annie P. Chiang, Alex A. Morgan, Alejandro Sweet-Cordero, Julien Sage, Atul J. Butte

Science Translational Medicine, 2011. DOI 10.1126/scitranslmed.3001318

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2017.

Replications

• Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data, Kandela & Aird (2017). eLife. Outcome recorded: mixed. Cimetidine treatment in a xenograft model using ACHN renal cell carcinoma cells did not differ from vehicle control treatment, similar to the original study Outcome read from the abstract. View paper

Cite this record

Sirota, M., Dudley, J. T., Kim, J., Chiang, A. P., Morgan, A. A., Sweet-Cordero, A., Sage, J., & Butte, A. J. (2011). Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data. Science Translational Medicine, 3(96). https://doi.org/10.1126/scitranslmed.3001318

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