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Serum Alpha-Linolenic Acid and Long-Term Multiple Sclerosis Activity and Progression

Marianna Cortese, Xiaojing Peng, Gilles Edan, Mark S. Freedman, Hans-Peter Hartung, Xavier Montalban, Rupert Sandbrink, Ernst-Wilhelm Radü, Frederik Barkhof, Eva-Maria Wicklein, Ludwig Kappos, Alberto Ascherio, Kjetil Bjornevik, Siegrid StrasserFuchs, Klaus V. Toyka, Christian Sindic, Benedicte Dubois, Dominique Dive, Valerie Delvaux, Jan Debruyne, Luanne Metz, George Rice, Marcelo Kremenchutzky, Pierre Duquette, Yves Lapierre, Mark Freedman, A. John Petkau, Anthony Traboulsee, Paul O'Connor, Petr Stourac, Radomir Talab, Martin Valis, Olga Zapletalova, Ivana Kovarova, Eva Medova, Jiri Fiedler, Jette Frederiksen, Bruno Brochet, Thibault Moreau, Patrick Vermersch, Jean Pelletier, Gilles Edan, Michel Clanet, David Brassat, Pierre Clavelou, Christine LebrunFrenay, Olivier Gout, Mikko Kallela, Tuula Pirttila, Juhani Ruutiainen, Juha-Pekka Erälinna, Keijo Koivisto, Mauri Reunanen, Irma Keskinarkaus, Irina Elovaara, Arno Villringer, Holger Altenkirch, Lars Bauer, Mario Ghazi, Christoph Pohl, Karl Wessel, Hans-Peter Hartung, Wolfgang Steinke, Bernd Kieseier, Hans Kölmel, Patrick Oschmann, Martin Berghoff, Ricarda Diem, Bernd Kitze, Alexander Dressel, Frank Hoffmann, Karl Baum, Stefan Jung, Hela-Felicitas Petereit, Dirk Reske, Michael Sailer, Jürgen Köhler, Björn Tackenberg, Luisa Klotz, Reinhard Hohlfeld, Tania Kuempfel, Karl-Heinz Henn, Andreas Steinbrecher, Klemens Angstwurm, Hayrettin Tumani, Ralf Gold, Peter Rieckmann, Christoph Kleinschnitz, Samuel Komoly, Gyula Gacs, Gabor Jakab, Gyula Panczel, Tunde Csepany, Laszlo Csiba, Laszlo Vecsei, Ariel Miller, Dimitrios Karussis, Joab Chapman, Angelo Ghezzi, Giancarlo Comi, Vittorio Martinelli, Paolo Gallo, Vittorio Cosi, Roberto Bergamaschi, Luca Durelli, Paola Cavalla, Kjell-Morten Myhr, Andrzej Szczudlik, Krzysztof Selmaj, Zbigniew Stelmasiak, Halina BarosikPsujek, Ryszard Podemski, Zdzislaw Maciejek, Slawomir Wawrzyniak, Luis Cunha, Sasa Sega-Jazbec, Xavier Montalbán, Txomin Arbizu, Albert Saiz Hinarejos, Joseba Barcena, Sergio Martínez Yélamos, Rafael Arroyo, Oscar Fernandez, Guillermo Izquierdo Ayuso, Bonaventura Casanova i Estruch, Jan Lycke, Ludwig Kappos, Ana de Vera, Stacey Wu, Jens Kuhle, W. Radue, Heinrich Mattle, Karsten Beer, Jürg Kesselring, Frederik Barkhof, Chris H. Polman, Bernard Uitdehaag, Bert Anten, Raymond Hupperts, Leo Visser, Richard Coleman, Jeremy Chataway, David H. Miller, Jonathan O'Riordan, Stephen Howell, Henry F. McFarlan

Neurology, 2025. DOI 10.1212/wnl.0000000000213905

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 successful.

Replications

• Alpha-linolenic acid associations with disability and brain volume in multiple sclerosis: a brief replication report, Korbmacher et al. (2026). Outcome recorded: successful. We replicate prior associations between higher serum ALA levels and reduced disability in MS and extend these by showing a beneficial association of serum ALA with brain volume. However, ALA did not predict long-term progression, limiting its prognostic value. View paper

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