A Genome-Wide Association Study Identifies Five Novel Genetic Markers for Trastuzumab-Induced Cardiotoxicity in Japanese Population

Mari Hara Nakano, Chihiro Udagawa, Arata Shimo, Yasuyuki Kojima, Reiko Yoshie, Hisamitsu Zaha, Norie Abe, Tokiwa Motonari, Mikiko Unesoko, Kenji Tamura, Tatsunori Shimoi, Masayuki Yoshida, Teruhiko Yoshida, Hiromi Sakamoto, Ken Kato, Taisei Mushiroda, Koichiro Tsugawa, Hitoshi Zembutsu

Biological and Pharmaceutical Bulletin, 2019. DOI 10.1248/bpb.b19-00527

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2022.

Replications

Replication Study for the Association of Five SNPs Identified by GWAS and Trastuzumab-Induced Cardiotoxicity in Japanese and Singaporean Cohorts, Udagawa et al. (2022). Biological and Pharmaceutical Bulletin. Outcome recorded: mixed. none of the SNPs showed a statistically significant association with trastuzumab-induced cardiotoxicity Outcome read from the abstract. View paper

Cite this record

Nakano, M. H., Udagawa, C., Shimo, A., Kojima, Y., Yoshie, R., Zaha, H., Abe, N., Motonari, T., Unesoko, M., Tamura, K., Shimoi, T., Yoshida, M., Yoshida, T., Sakamoto, H., Kato, K., Mushiroda, T., Tsugawa, K., & Zembutsu, H. (2019). A Genome-Wide Association Study Identifies Five Novel Genetic Markers for Trastuzumab-Induced Cardiotoxicity in Japanese Population. Biological and Pharmaceutical Bulletin, 42(12), 2045–2053. https://doi.org/10.1248/bpb.b19-00527

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