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Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor

Matthew C. Keller, Matthew A. Simonson, Stephan Ripke, Ben M. Neale, Pablo V. Gejman, Daniel P. Howrigan, Sang Hong Lee, Todd Lencz, Douglas F. Levinson, Patrick F. Sullivan

PLoS Genetics, 2012. DOI 10.1371/journal.pgen.1002656

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 failed. The earliest on record is from 2016.

Replications

• No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication Study, Johnson et al. (2016). PLOS Genetics. Outcome recorded: failed. we were unable to replicate the significant association between ROH burden and schizophrenia in the independent PGC phase II data Outcome read from the abstract. View paper

Cite this record

Keller, M. C., Simonson, M. A., Ripke, S., Neale, B. M., Gejman, P. V., Howrigan, D. P., Lee, S. H., Lencz, T., Levinson, D. F., & Sullivan, P. F. (2012). Runs of Homozygosity Implicate Autozygosity as a Schizophrenia Risk Factor. PLoS Genetics, 8(4), e1002656. https://doi.org/10.1371/journal.pgen.1002656

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