Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases

John R. B. Perry, Benjamin F. Voight, Loïc Yengo, Najaf Amin, Josée Dupuis, Martha Ganser, Harald Grallert, Pau Navarro, Man Li, Lu Qi, Valgerdur Steinthorsdottir, Robert A. Scott, Peter Almgren, Dan E. Arking, Yurii Aulchenko, Beverley Balkau, Rafn Benediktsson, Richard N. Bergman, Eric Boerwinkle, Lori Bonnycastle, Noël P. Burtt, Harry Campbell, Guillaume Charpentier, Francis S. Collins, Christian Gieger, Todd Green, Samy Hadjadj, Andrew T. Hattersley, Christian Herder, Albert Hofman, Andrew D. Johnson, Anna Kottgen, Peter Kraft, Yann Labrune, Claudia Langenberg, Alisa K. Manning, Karen L. Mohlke, Andrew P. Morris, Ben Oostra, James Pankow, Ann-Kristin Petersen, Peter P. Pramstaller, Inga Prokopenko, Wolfgang Rathmann, William Rayner, Michael Roden, Igor Rudan, Denis Rybin, Laura J. Scott, Gunnar Sigurdsson, Rob Sladek, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Jaakko Tuomilehto, Andre G. Uitterlinden, Sidonie Vivequin, Michael N. Weedon, Alan F. Wright, Frank B. Hu, Thomas Illig, Linda Kao, James B. Meigs, James F. Wilson, Kari Stefansson, Cornelia van Duijn, David Altschuler, Andrew D. Morris, Michael Boehnke, Mark I. McCarthy, Philippe Froguel, Colin N. A. Palmer, Nicholas J. Wareham, Leif Groop, Timothy M. Frayling, Stéphane Cauchi

PLoS Genetics, 2012. DOI 10.1371/journal.pgen.1002741

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 failed. The earliest on record is from 2015.

Replications

Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes, Matsuba et al. (2015). PLOS ONE. Outcome recorded: failed. The LAMA1 locus has been shown to be associated with lean type 2 diabetes, but not with obese type 2 diabetes, in the European GWAS [15]. We did not replicate the original associations (p ! 0.05 adjusted for sex, age and BMI; Table 5, S3 Table). Read from discussion. View paper

Cite this record

Perry, J. R. B., Voight, B. F., Yengo, L., Amin, N., Dupuis, J., Ganser, M., Grallert, H., Navarro, P., Li, M., Qi, L., Steinthorsdottir, V., Scott, R. A., Almgren, P., Arking, D. E., Aulchenko, Y., Balkau, B., Benediktsson, R., Bergman, R. N., Boerwinkle, E., et al. (2012). Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases. PLoS Genetics, 8(5), e1002741. https://doi.org/10.1371/journal.pgen.1002741

Other studies in the atlas

Failed replications · Successful replications · All browse pages