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Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF

Sonja J. Heidorn, Carla Milagre, Steven Whittaker, Arnaud Nourry, Ion Niculescu-Duvas, Nathalie Dhomen, Jahan Hussain, Jorge S. Reis-Filho, Caroline J. Springer, Catrin Pritchard, Richard Marais

Cell, 2010. DOI 10.1016/j.cell.2009.12.040

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed.

Replications

• Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology, Errington et al. (2021). Outcome recorded: mixed. "To summarize, we found results that were in the same direction as the original study and statistically significant, except for the effect of D04 cells treated with SB590885, which was not statistically significant." View paper

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