IDH mutation impairs histone demethylation and results in a block to cell differentiation

Chao Lu, Patrick S. Ward, Gurpreet S. Kapoor, Dan Rohle, Sevin Turcan, Omar Abdel-Wahab, Christopher R. Edwards, Raya Khanin, Maria E. Figueroa, Ari Melnick, Kathryn E. Wellen, Donald M. O'Rourke, Shelley L. Berger, Timothy A. Chan, Ross L. Levine, Ingo K. Mellinghoff, Craig B. Thompson

Nature, 2012. DOI 10.1038/nature10860

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2021.

Replications

Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology, Errington et al. (2021). eLife. Outcome recorded: mixed. "To summarize, this replication attempt was not further continued and thus these data are unable to address whether mutant IDH2 is correlated with a block in differentiation and if this effect was mediated by the histone demethylase KDM4C." Outcome read from the full text. View paper

Cite this record

Lu, C., Ward, P. S., Kapoor, G. S., Rohle, D., Turcan, S., Abdel-Wahab, O., Edwards, C. R., Khanin, R., Figueroa, M. E., Melnick, A., Wellen, K. E., O'Rourke, D. M., Berger, S. L., Chan, T. A., Levine, R. L., Mellinghoff, I. K., & Thompson, C. B. (2012). IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature, 483(7390), 474–478. https://doi.org/10.1038/nature10860

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