FLoRA Replication Atlas › Browse

IDH mutation impairs histone demethylation and results in a block to cell differentiation

Chao Lu, Patrick S. Ward, Gurpreet S. Kapoor, Dan Rohle, Sevin Turcan, Omar Abdel-Wahab, Christopher R. Edwards, Raya Khanin, Maria E. Figueroa, Ari Melnick, Kathryn E. Wellen, Donald M. O'Rourke, Shelley L. Berger, Timothy A. Chan, Ross L. Levine, Ingo K. Mellinghoff, Craig B. Thompson

Nature, 2012. DOI 10.1038/nature10860

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed.

Replications

• Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology, Errington et al. (2021). Outcome recorded: mixed. "To summarize, this replication attempt was not further continued and thus these data are unable to address whether mutant IDH2 is correlated with a block in differentiation and if this effect was mediated by the histone demethylase KDM4C." View paper

Other studies in the atlas

• Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
• Growth and survival: The moderating effects of local agglomeration and local market struc…
• Is The Venture Growth-Survival Relationship Inverted U-Shaped or Not? A Replication Study
• Explaining Why the Computer Says No: Algorithmic Transparency Affects the Perceived Trust…
• A Replication of "Explaining Why the Computer Says No: Algorithmic Transparency Affects t…
• Teaching mathematics with technology: a multidimensional analysis of teacher beliefs

Failed replications · Successful replications · All browse pages