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Melanoma genome sequencing reveals frequent PREX2 mutations

Michael F. Berger, Eran Hodis, Timothy P. Heffernan, Yonathan Lissanu Deribe, Michael S. Lawrence, Alexei Protopopov, Elena Ivanova, Ian R. Watson, Elizabeth Nickerson, Papia Ghosh, Hailei Zhang, Rhamy Zeid, Xiaojia Ren, Kristian Cibulskis, Andrey Y. Sivachenko, Nikhil Wagle, Antje Sucker, Carrie Sougnez, Robert Onofrio, Lauren Ambrogio, Daniel Auclair, Timothy Fennell, Scott L. Carter, Yotam Drier, Petar Stojanov, Meredith A. Singer, Douglas Voet, Rui Jing, Gordon Saksena, Jordi Barretina, Alex H. Ramos, Trevor J. Pugh, Nicolas Stransky, Melissa Parkin, Wendy Winckler, Scott Mahan, Kristin Ardlie, Jennifer Baldwin, Jennifer Wargo, Dirk Schadendorf, Matthew Meyerson, Stacey B. Gabriel, Todd R. Golub, Stephan N. Wagner, Eric S. Lander, Gad Getz, Lynda Chin, Levi A. Garraway

Nature, 2012. DOI 10.1038/nature11071

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 failed. The earliest on record is from 2017.

Replications

• Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations, Horrigan et al. (2017). eLife. Outcome recorded: failed. resulted in no statistically significant difference in tumor-free survival driven by PREX2 variants Outcome read from the abstract. View paper

Cite this record

Berger, M. F., Hodis, E., Heffernan, T. P., Deribe, Y. L., Lawrence, M. S., Protopopov, A., Ivanova, E., Watson, I. R., Nickerson, E., Ghosh, P., Zhang, H., Zeid, R., Ren, X., Cibulskis, K., Sivachenko, A. Y., Wagle, N., Sucker, A., Sougnez, C., Onofrio, R., … Garraway, L. A. (2012). Melanoma genome sequencing reveals frequent PREX2 mutations. Nature, 485(7399), 502–506. https://doi.org/10.1038/nature11071

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• Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
• Diverse somatic mutation patterns and pathway alterations in human cancers
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• COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
• IDH mutation impairs histone demethylation and results in a block to cell differentiation

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