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A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Laura Poliseno, Leonardo Salmena, Jiangwen Zhang, Brett Carver, William J. Haveman, Pier Paolo Pandolfi

Nature, 2010. DOI 10.1038/nature09144

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2020.

Replications

• Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology, Kerwin et al. (2020). eLife. Outcome recorded: mixed. "PTEN and/or PTENP1 depletion in DU145 cells decreased PTEN protein expression, which was similar to the original study." "We found PTEN 3'UTR overexpression in DU145 cells did not impact PTENP1 expression, while the original study reported PTEN 3'UTR increased PTENP1 levels." Outcome read from the full text. View paper

Cite this record

Poliseno, L., Salmena, L., Zhang, J., Carver, B., Haveman, W. J., & Pandolfi, P. P. (2010). A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature, 465(7301), 1033–1038. https://doi.org/10.1038/nature09144

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