FLoRA Replication Atlas › Browse

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Laura Poliseno, Leonardo Salmena, Jiangwen Zhang, Brett Carver, William J. Haveman, Pier Paolo Pandolfi

Nature, 2010. DOI 10.1038/nature09144

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed.

Replications

• Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology, Kerwin et al. (2020). Outcome recorded: mixed. "PTEN and/or PTENP1 depletion in DU145 cells decreased PTEN protein expression, which was similar to the original study." "We found PTEN 3'UTR overexpression in DU145 cells did not impact PTENP1 expression, while the original study reported PTEN 3'UTR increased PTENP1 levels." View paper

Other studies in the atlas

• Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates t…
• Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
• COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
• IDH mutation impairs histone demethylation and results in a block to cell differentiation
• Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells
• Growth and survival: The moderating effects of local agglomeration and local market struc…

Failed replications · Successful replications · All browse pages