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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

Louis Vermeulen, Felipe De Sousa E Melo, Maartje van der Heijden, Kate Cameron, Joan H. de Jong, Tijana Borovski, Jurriaan B. Tuynman, Matilde Todaro, Christian Merz, Hans Rodermond, Martin R. Sprick, Kristel Kemper, Dick J. Richel, Giorgio Stassi, Jan Paul Medema

Nature Cell Biology, 2010. DOI 10.1038/ncb2048

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed.

Replications

• Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment, Essex et al. (2019). Outcome recorded: mixed. When tested in vivo, we did not find a difference in tumorigenicity between high and low Wnt activity, while the original study found cells with high Wnt activity were more effective in inducing tumors View paper

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