Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis

Serena Sanna, Maristella Pitzalis, Magdalena Zoledziewska, Ilenia Zara, Carlo Sidore, Raffaele Murru, Michael B Whalen, Fabio Busonero, Andrea Maschio, Gianna Costa, Maria Cristina Melis, Francesca Deidda, Fausto Poddie, Laura Morelli, Gabriele Farina, Yun Li, Mariano Dei, Sandra Lai, Antonella Mulas, Gianmauro Cuccuru, Eleonora Porcu, Liming Liang, Patrizia Zavattari, Loredana Moi, Elisa Deriu, M Francesca Urru, Michele Bajorek, Maria Anna Satta, Eleonora Cocco, Paola Ferrigno, Stefano Sotgiu, Maura Pugliatti, Sebastiano Traccis, Andrea Angius, Maurizio Melis, Giulio Rosati, Gonçalo R Abecasis, Manuela Uda, Maria Giovanna Marrosu, David Schlessinger, Francesco Cucca

Nature Genetics, 2010. DOI 10.1038/ng.584

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 successful.

Replications

Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population: Table 1, Corrado et al. (2010). Outcome recorded: successful. the common allele T of rs9657904 is significantly positively associated (one-tailed p=7.35×10 -5 ) and with a comparable effect size with MS (OR=1.31, 95% CI 1.14 to 1.52). View paper

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