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A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis

Yohei Takahashi, Ikuyo Kou, Atsushi Takahashi, Todd A Johnson, Katsuki Kono, Noriaki Kawakami, Koki Uno, Manabu Ito, Shohei Minami, Haruhisa Yanagida, Hiroshi Taneichi, Taichi Tsuji, Teppei Suzuki, Hideki Sudo, Toshiaki Kotani, Kota Watanabe, Kazuhiro Chiba, Naoya Hosono, Naoyuki Kamatani, Tatsuhiko Tsunoda, Yoshiaki Toyama, Michiaki Kubo, Morio Matsumoto, Shiro Ikegawa

Nature Genetics, 2011. DOI 10.1038/ng.974

Has this study been replicated?

The atlas records 2 replications of this study. Recorded outcomes: 2 successful.

Replications

• SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese, Fan et al. (2012). Outcome recorded: successful. The results of this study confirm that SNP rs11190870 is associated with AIS. View paper
• Association between Common Variants near LBX1 and Adolescent Idiopathic Scoliosis Replicated in the Chinese Han Population, Gao et al. (2013). Outcome recorded: successful. It successfully replicates the results of the GWAS, which was performed in a Japanese population. View paper

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