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Genome-wide association meta-analysis identifies 29 new acne susceptibility loci

Brittany L. Mitchell, Jake R. Saklatvala, Nick Dand, Fiona A. Hagenbeek, Xin Li, Josine L. Min, Laurent Thomas, Meike Bartels, Jouke Jan Hottenga, Michelle K. Lupton, Dorret I. Boomsma, Xianjun Dong, Kristian Hveem, Mari Løset, Nicholas G. Martin, Jonathan N. Barker, Jiali Han, Catherine H. Smith, Miguel E. Rentería, Michael A. Simpson

Nature Communications, 2022. DOI 10.1038/s41467-022-28252-5

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed.

Replications

• Replication of acne susceptibility loci and gene–environment interactions with screen time in Singapore and Malaysia Chinese population, Liu et al. (2026). Outcome recorded: mixed. we evaluated 88 previously reported acne-associated variants in 2741 acne cases and 2235 controls from the Singapore/Malaysia Cross-sequential Genetic Epidemiology Study. Two association signals were replicated at Bonferroni-corrected significance View paper

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