Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease

Violeta Raverdy, Federica Tavaglione, Estelle Chatelain, Guillaume Lassailly, Antonio De Vincentis, Umberto Vespasiani-Gentilucci, Sami F. Qadri, Robert Caiazzo, Helene Verkindt, Chiara Saponaro, Julie Kerr-Conte, Gregory Baud, Camille Marciniak, Mikael Chetboun, Naima Oukhouya-Daoud, Samuel Blanck, Jimmy Vandel, Lisa Olsson, Rima Chakaroun, Viviane Gnemmi, Emmanuelle Leteurtre, Philippe Lefebvre, Joel T. Haas, Hannele Yki-Järvinen, Sven Francque, Bart Staels, Carel W. Le Roux, Valentina Tremaroli, Philippe Mathurin, Guillemette Marot, Stefano Romeo, François Pattou

Nature Medicine, 2024. DOI 10.1038/s41591-024-03283-1

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2026.

Replications

Population‐based cohort validation and replication reveals limited generalizability of cluster‐based MASLD subtypes, Wu et al. (2026). Diabetes, Obesity and Metabolism. Outcome recorded: mixed. Individual cluster assignments showed limited reproducibility between the validation and replication analyses, although the overall clustering pattern was preserved. Outcome read from the abstract. View paper

Cite this record

Raverdy, V., Tavaglione, F., Chatelain, E., Lassailly, G., De Vincentis, A., Vespasiani-Gentilucci, U., Qadri, S. F., Caiazzo, R., Verkindt, H., Saponaro, C., Kerr-Conte, J., Baud, G., Marciniak, C., Chetboun, M., Oukhouya-Daoud, N., Blanck, S., Vandel, J., Olsson, L., Chakaroun, R., … Pattou, F. (2024). Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease. Nature Medicine, 30(12), 3624–3633. https://doi.org/10.1038/s41591-024-03283-1

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