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Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease

Violeta Raverdy, Federica Tavaglione, Estelle Chatelain, Guillaume Lassailly, Antonio De Vincentis, Umberto Vespasiani-Gentilucci, Sami F. Qadri, Robert Caiazzo, Helene Verkindt, Chiara Saponaro, Julie Kerr-Conte, Gregory Baud, Camille Marciniak, Mikael Chetboun, Naima Oukhouya-Daoud, Samuel Blanck, Jimmy Vandel, Lisa Olsson, Rima Chakaroun, Viviane Gnemmi, Emmanuelle Leteurtre, Philippe Lefebvre, Joel T. Haas, Hannele Yki-Järvinen, Sven Francque, Bart Staels, Carel W. Le Roux, Valentina Tremaroli, Philippe Mathurin, Guillemette Marot, Stefano Romeo, François Pattou

Nature Medicine, 2024. DOI 10.1038/s41591-024-03283-1

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed.

Replications

• Population‐based cohort validation and replication reveals limited generalizability of cluster‐based MASLD subtypes, Wu et al. (2026). Outcome recorded: mixed. Individual cluster assignments showed limited reproducibility between the validation and replication analyses, although the overall clustering pattern was preserved. View paper

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Failed replications · Successful replications · All browse pages