A common variant associated with prostate cancer in European and African populations

Laufey T Amundadottir, Patrick Sulem, Julius Gudmundsson, Agnar Helgason, Adam Baker, Bjarni A Agnarsson, Asgeir Sigurdsson, Kristrun R Benediktsdottir, Jean-Baptiste Cazier, Jesus Sainz, Margret Jakobsdottir, Jelena Kostic, Droplaug N Magnusdottir, Shyamali Ghosh, Kari Agnarsson, Birgitta Birgisdottir, Louise Le Roux, Adalheidur Olafsdottir, Thorarinn Blondal, Margret Andresdottir, Olafia Svandis Gretarsdottir, Jon T Bergthorsson, Daniel Gudbjartsson, Arnaldur Gylfason, Gudmar Thorleifsson, Andrei Manolescu, Kristleifur Kristjansson, Gudmundur Geirsson, Helgi Isaksson, Julie Douglas, Jan-Erik Johansson, Katarina Bälter, Fredrik Wiklund, James E Montie, Xiaoying Yu, Brian K Suarez, Carole Ober, Kathleen A Cooney, Henrik Gronberg, William J Catalona, Gudmundur V Einarsson, Rosa B Barkardottir, Jeffrey R Gulcher, Augustine Kong, Unnur Thorsteinsdottir, Kari Stefansson

Nature Genetics, 2006. DOI 10.1038/ng1808

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 successful. The earliest on record is from 2011.

Replications

Chromosome 8q24 variants are associated with prostate cancer risk in a high risk population of African ancestry, Okobia et al. (2011). The Prostate. Outcome recorded: successful. The replication of the association of chromosome 8q24 variants with increased prostate cancer risk in Tobago men and the higher frequency of the risk alleles in controls in populations of African ancestry further strengthens the possible role of this genomic region in the disproportionate higher burden of prostate cancer in men of African ancestry. Outcome read from the abstract. View paper

Cite this record

Amundadottir, L. T., Sulem, P., Gudmundsson, J., Helgason, A., Baker, A., Agnarsson, B. A., Sigurdsson, A., Benediktsdottir, K. R., Cazier, J.-B., Sainz, J., Jakobsdottir, M., Kostic, J., Magnusdottir, D. N., Ghosh, S., Agnarsson, K., Birgisdottir, B., Le Roux, L., Olafsdottir, A., Blondal, T., … Stefansson, K. (2006). A common variant associated with prostate cancer in European and African populations. Nature Genetics, 38(6), 652–658. https://doi.org/10.1038/ng1808

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