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Common variants at 6p21.1 are associated with large artery atherosclerotic stroke

Elizabeth G Holliday, Jane M Maguire, Tiffany-Jane Evans, Simon A Koblar, Jim Jannes, Jonathan W Sturm, Graeme J Hankey, Ross Baker, Jonathan Golledge, Mark W Parsons, Rainer Malik, Mark McEvoy, Erik Biros, Martin D Lewis, Lisa F Lincz, Roseanne Peel, Christopher Oldmeadow, Wayne Smith, Pablo Moscato, Simona Barlera, Steve Bevan, Joshua C Bis, Eric Boerwinkle, Giorgio B Boncoraglio, Thomas G Brott, Robert D Brown, Yu-Ching Cheng, John W Cole, Ioana Cotlarciuc, William J Devan, Myriam Fornage, Karen L Furie, Sólveig Grétarsdóttir, Andreas Gschwendtner, M Arfan Ikram, W T Longstreth, James F Meschia, Braxton D Mitchell, Thomas H Mosley, Michael A Nalls, Eugenio A Parati, Bruce M Psaty, Pankaj Sharma, Kari Stefansson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Matthew Traylor, Benjamin F J Verhaaren, Kerri L Wiggins, Bradford B Worrall, Cathie Sudlow, Peter M Rothwell, Martin Farrall, Martin Dichgans, Jonathan Rosand, Hugh S Markus, Rodney J Scott, Christopher Levi, John Attia

Nature Genetics, 2012. DOI 10.1038/ng.2397

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2017.

Replications

• A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study, Hauer et al. (2017). Scientific Reports. Outcome recorded: mixed. In conclusion, we validated two loci (4q25, 16q22) associated with CE. In addition, our study may suggest that the association of locus 16q22 may not be limited to CE, but also includes overall IS. Outcome read from the discussion. View paper

Cite this record

, Holliday, E. G., Maguire, J. M., Evans, T.-J., Koblar, S. A., Jannes, J., Sturm, J. W., Hankey, G. J., Baker, R., Golledge, J., Parsons, M. W., Malik, R., McEvoy, M., Biros, E., Lewis, M. D., Lincz, L. F., Peel, R., et al. (2012). Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nature Genetics, 44(10), 1147–1151. https://doi.org/10.1038/ng.2397

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