Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke

Céline Bellenguez, Steve Bevan, Andreas Gschwendtner, Chris C A Spencer, Annette I Burgess, Matti Pirinen, Caroline A Jackson, Matthew Traylor, Amy Strange, Zhan Su, Gavin Band, Paul D Syme, Rainer Malik, Joanna Pera, Bo Norrving, Robin Lemmens, Colin Freeman, Renata Schanz, Tom James, Deborah Poole, Lee Murphy, Helen Segal, Lynelle Cortellini, Yu-Ching Cheng, Daniel Woo, Michael A Nalls, Bertram Müller-Myhsok, Christa Meisinger, Udo Seedorf, Helen Ross-Adams, Steven Boonen, Dorota Wloch-Kopec, Valerie Valant, Julia Slark, Karen Furie, Hossein Delavaran, Cordelia Langford, Panos Deloukas, Sarah Edkins, Sarah Hunt, Emma Gray, Serge Dronov, Leena Peltonen, Solveig Gretarsdottir, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Kari Stefansson, Giorgio B Boncoraglio, Eugenio A Parati, John Attia, Elizabeth Holliday, Chris Levi, Maria-Grazia Franzosi, Anuj Goel, Anna Helgadottir, Jenefer M Blackwell, Elvira Bramon, Matthew A Brown, Juan P Casas, Aiden Corvin, Audrey Duncanson, Janusz Jankowski, Christopher G Mathew, Colin N A Palmer, Robert Plomin, Anna Rautanen, Stephen J Sawcer, Richard C Trembath, Ananth C Viswanathan, Nicholas W Wood, Bradford B Worrall, Steven J Kittner, Braxton D Mitchell, Brett Kissela, James F Meschia, Vincent Thijs, Arne Lindgren, Mary Joan Macleod, Agnieszka Slowik, Matthew Walters, Jonathan Rosand, Pankaj Sharma, Martin Farrall, Cathie L M Sudlow, Peter M Rothwell, Martin Dichgans, Peter Donnelly, Hugh S Markus

Nature Genetics, 2012. DOI 10.1038/ng.1081

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2017.

Replications

A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study, Hauer et al. (2017). Scientific Reports. Outcome recorded: mixed. Other loci previously associated with IS and/or its subtypes were not confirmed. In conclusion, we validated two loci (4q25, 16q22) associated with CE. In addition, our study may suggest that the association of locus 16q22 may not be limited to CE, but also includes overall IS. Read from discussion. View paper

Cite this record

, Bellenguez, C., Bevan, S., Gschwendtner, A., Spencer, C. C. A., Burgess, A. I., Pirinen, M., Jackson, C. A., Traylor, M., Strange, A., Su, Z., Band, G., Syme, P. D., Malik, R., Pera, J., Norrving, B., Lemmens, R., Freeman, C., et al. (2012). Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke. Nature Genetics, 44(3), 328–333. https://doi.org/10.1038/ng.1081

Other studies in the atlas

Failed replications · Successful replications · All browse pages