Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Richard Karlsson Linnér, Travis T. Mallard, Peter B. Barr, Sandra Sanchez-Roige, James W. Madole, Morgan N. Driver, Holly E. Poore, Ronald de Vlaming, Andrew D. Grotzinger, Jorim J. Tielbeek, Emma C. Johnson, Mengzhen Liu, Sara Brin Rosenthal, Trey Ideker, Hang Zhou, Rachel L. Kember, Joëlle A. Pasman, Karin J. H. Verweij, Dajiang J. Liu, Scott Vrieze, Bernice Porjesz, Victor Hesselbrock, Tatiana M. Foroud, Arpana Agrawal, Howard J. Edenberg, John I. Nurnberger Jr, Yunlong Liu, Samuel Kuperman, John Kramer, Jacquelyn L. Meyer, Chella Kamarajan, Ashwini K. Pandey, Laura Bierut, John Rice, Kathleen K. Bucholz, Marc A. Schuckit, Jay Tischfield, Andrew Brooks, Ronald P. Hart, Laura Almasy, Danielle M. Dick, Jessica E. Salvatore, Allison Goate, Manav Kapoor, Paul Slesinger, Denise M. Scott, Lance Bauer, Leah Wetherill, Xiaoling Xuei, Dongbing Lai, Sean J. O'Connor, Martin H. Plawecki, Spencer Lourens, Laura Acion, Grace Chan, David B. Chorlian, Jian Zhang, Sivan Kinreich, Gayathri Pandey, Michael J. Chao, Andrey P. Anokhin, Vivia V. McCutcheon, Scott Saccone, Fazil Aliev, Peter B. Barr, Hemin Chin, Abbas Parsian, Henry R. Kranzler, Joel Gelernter, Kathleen Mullan Harris, Elliot M. Tucker-Drob, Irwin D. Waldman, Abraham A. Palmer, K. Paige Harden, Philipp D. Koellinger, Danielle M. Dick

Nature Neuroscience, 2021. DOI 10.1038/s41593-021-00908-3

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2025.

Replications

Using polygenic scores to assess liability to antisocial behavior, Kazantseva et al. (2025). Vavilov Journal of Genetics and Breeding. Outcome recorded: mixed. PGS alone explained a small proportion of variance in liability to ASB (1.1–1.5 %), while the inclusion of social parameters increased variance explained (16.2–21.2 %). Outcome read from the abstract. View paper

Cite this record

Karlsson Linnér, R., Mallard, T. T., Barr, P. B., Sanchez-Roige, S., Madole, J. W., Driver, M. N., Poore, H. E., de Vlaming, R., Grotzinger, A. D., Tielbeek, J. J., Johnson, E. C., Liu, M., Rosenthal, S. B., Ideker, T., Zhou, H., Kember, R. L., Pasman, J. A., Verweij, K. J. H., Liu, D. J., … Dick, D. M. (2021). Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Nature Neuroscience, 24(10), 1367–1376. https://doi.org/10.1038/s41593-021-00908-3

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