Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease

J Deckert, M M Nöthen, P Franke, C Delmo, J Fritze, M Knapp, W Maier, H Beckmann, P Propping

Molecular Psychiatry, 1998. DOI 10.1038/sj.mp.4000345

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed.

Evidence for Genetic Linkage Between a Polymorphism in the Adenosine 2A Receptor and Panic Disorder, Hamilton et al. (2003). Outcome recorded: mixed. Our findings provide evidence for a susceptibility locus for panic disorder, and possibly including agoraphobia, either within the ADORA2A gene or in a nearby region of chromosome 22, and serves as the first successful candidate gene replication study in panic disorder. View paper