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Genome-Wide Association Study Identifies Variants Associated With Autoimmune Hepatitis Type 1

Ynto S. de Boer, Nicole M.F. van Gerven, Antonie Zwiers, Bart J. Verwer, Bart van Hoek, Karel J. van Erpecum, Ulrich Beuers, Henk R. van Buuren, Joost P.H. Drenth, Jannie W. den Ouden, Robert C. Verdonk, Ger H. Koek, Johannes T. Brouwer, Maureen M.J. Guichelaar, Jan M. Vrolijk, Georg Kraal, Chris J.J. Mulder, Carin M.J. van Nieuwkerk, Janett Fischer, Thomas Berg, Felix Stickel, Christoph Sarrazin, Christoph Schramm, Ansgar W. Lohse, Christina Weiler-Normann, Markus M. Lerch, Matthias Nauck, Henry Völzke, Georg Homuth, Elisabeth Bloemena, Hein W. Verspaget, Vinod Kumar, Alexandra Zhernakova, Cisca Wijmenga, Lude Franke, Gerd Bouma

Gastroenterology, 2014. DOI 10.1053/j.gastro.2014.04.022

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 successful.

Replications

• Association of a single nucleotide polymorphism upstream of ICOS with Japanese autoimmune hepatitis type 1, Higuchi et al. (2016). Outcome recorded: successful. We found that rs4325730 is associated with AIH (P=0.0173, odds ratio (OR) 1.30, 95% confidence interval (CI) 1.05–1.62). View paper

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