High Temperature Requirement Factor A1 (HTRA1) Gene Regulates Angiogenesis through Transforming Growth Factor-β Family Member Growth Differentiation Factor 6

Li Zhang, Siok Lam Lim, Hongjun Du, Ming Zhang, Igor Kozak, Gregory Hannum, Xiaolei Wang, Hong Ouyang, Guy Hughes, Ling Zhao, Xuemei Zhu, Clara Lee, Zhiguang Su, Xinrong Zhou, Robert Shaw, Dongho Geum, Xinran Wei, Jin Zhu, Trey Ideker, Chio Oka, Ningli Wang, Zhenglin Yang, Peter X. Shaw, Kang Zhang

Journal of Biological Chemistry, 2012. DOI 10.1074/jbc.m111.275990

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2014.

Replications

Association of rs6982567 near GDF6with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy in a Han Chinese cohort, Ji et al. (2014). BMC Ophthalmology. Outcome recorded: mixed. Growth differentiation factor 6 (GDF6) has been reported to be a novel disease gene for age-related macular degeneration (AMD) in Caucasians. Outcome read from the abstract. View paper

Cite this record

Zhang, L., Lim, S. L., Du, H., Zhang, M., Kozak, I., Hannum, G., Wang, X., Ouyang, H., Hughes, G., Zhao, L., Zhu, X., Lee, C., Su, Z., Zhou, X., Shaw, R., Geum, D., Wei, X., Zhu, J., Ideker, T., Oka, C., Wang, N., Yang, Z., Shaw, P. X., & Zhang, K. (2012). High Temperature Requirement Factor A1 (HTRA1) Gene Regulates Angiogenesis through Transforming Growth Factor-β Family Member Growth Differentiation Factor 6. Journal of Biological Chemistry, 287(2), 1520–1526. https://doi.org/10.1074/jbc.m111.275990

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