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Significant Linkage of Parkinson Disease to Chromosome 2q36-37

Nathan Pankratz, William C. Nichols, Sean K. Uniacke, Cheryl Halter, Alice Rudolph, Cliff Shults, P. Michael Conneally, Tatiana Foroud

The American Journal of Human Genetics, 2003. DOI 10.1086/374383

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 failed.

Replications

• PARK11 is not linked with Parkinson's disease in European families, Prestel et al. (2004). Outcome recorded: failed. Linkage analysis in 153 individuals from 45 European families with a strong family history of PD did not show any significant LOD score in this region. View paper

Other studies in the atlas

• PARK11 is not linked with Parkinson's disease in European families
• Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
• Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity
• Saccade preparation inhibits reorienting to recently attended locations
• Endogenous saccade preparation does not produce inhibition of return: Failure to replicat…
• The −174 G/C polymorphism of the IL6 gene is associated with elite power performance

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