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In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis

Nicole C. Kleinstreuer, David J. Dix, Keith A. Houck, Robert J. Kavlock, Thomas B. Knudsen, Matthew T. Martin, Katie B. Paul, David M. Reif, Kevin M. Crofton, Kerry Hamilton, Ronald Hunter, Imran Shah, Richard S. Judson

Toxicological Sciences, 2012. DOI 10.1093/toxsci/kfs285

Has this study been replicated?

The atlas records 1 reproduction of this study. Recorded outcomes: 1 mixed.

Reproductions

• How well can in vitro data predict in vivo effects of chemicals? Rodent carcinogenicity as a case study, Anthony (Tony) Cox et al. (2016). Regulatory Toxicology and Pharmacology. Outcome recorded: computationally reproducible, robustness challenges. Using independently developed software to validate the computational results, we replicated the majority of the results reported. Outcome read from the abstract. View paper

Cite this record

Kleinstreuer, N. C., Dix, D. J., Houck, K. A., Kavlock, R. J., Knudsen, T. B., Martin, M. T., Paul, K. B., Reif, D. M., Crofton, K. M., Hamilton, K., Hunter, R., Shah, I., & Judson, R. S. (2012). In Vitro Perturbations of Targets in Cancer Hallmark Processes Predict Rodent Chemical Carcinogenesis. Toxicological Sciences, 131(1), 40–55. https://doi.org/10.1093/toxsci/kfs285

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