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Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data‐Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders

Yuka Yasuda, Satsuki Ito, Junya Matsumoto, Naohiro Okada, Toshiaki Onitsuka, Masashi Ikeda, Itaru Kushima, Chika Sumiyoshi, Masaki Fukunaga, Kiyotaka Nemoto, Kenichiro Miura, Naoki Hashimoto, Kazutaka Ohi, Tsutomu Takahashi, Daiki Sasabayashi, Michihiko Koeda, Hidenaga Yamamori, Michiko Fujimoto, Harumasa Takano, Naomi Hasegawa, Hisashi Narita, Maeri Yamamoto, Khin Khin Tha, Masataka Kikuchi, Toshiharu Kamishikiryo, Eri Itai, Yoshiro Okubo, Amane Tateno, Motoaki Nakamura, Manabu Kubota, Hiroyuki Igarashi, Yoji Hirano, Go Okada, Jun Miyata, Shusuke Numata, Osamu Abe, Reiji Yoshimura, Shin Nakagawa, Hidenori Yamasue, Norio Ozaki, Kiyoto Kasai, Ryota Hashimoto

Neuropsychopharmacology Reports, 2025. DOI 10.1002/npr2.70010

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 successful. The earliest on record is from 2026.

Replications

• A Data‐Driven Psychiatric Disorder Subtype Defined by Significant Enlarged Ventricles and Cognitive Impairment: A Replication Study, Onitsuka et al. (2026). Neuropsychopharmacology Reports. Outcome recorded: successful. This study validated the existence of the EVCI subgroup in independent cohorts, thus supporting our previous findings. Outcome read from the abstract. View paper

Cite this record

Yasuda, Y., Ito, S., Matsumoto, J., Okada, N., Onitsuka, T., Ikeda, M., Kushima, I., Sumiyoshi, C., Fukunaga, M., Nemoto, K., Miura, K., Hashimoto, N., Ohi, K., Takahashi, T., Sasabayashi, D., Koeda, M., Yamamori, H., Fujimoto, M., Takano, H., et al. (2025). Proposal for a Novel Classification of Patients With Enlarged Ventricles and Cognitive Impairment Based on Data‐Driven Analysis of Neuroimaging Results in Patients With Psychiatric Disorders. Neuropsychopharmacology Reports, 45(1). Portico. https://doi.org/10.1002/npr2.70010

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