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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen, Barbara J. Brandhuber, Daniel J. Anderson, Ryan Alvarado, Mary J. C. Ludlam, David Stokoe, Susan L. Gloor, Guy Vigers, Tony Morales, Ignacio Aliagas, Bonnie Liu, Steve Sideris, Klaus P. Hoeflich, Bijay S. Jaiswal, Somasekar Seshagiri, Hartmut Koeppen, Marcia Belvin, Lori S. Friedman, Shiva Malek

Nature, 2010. DOI 10.1038/nature08833

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 failed.

Replications

• Replication Study: RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth, Pelech et al. (2021). Outcome recorded: failed. "The original study reported analogous results with GDC-0879, which was not observed in this replication." View paper

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• A two-lab direct replication attempt of Southgate, Senju and Csibra (2007)

Failed replications · Successful replications · All browse pages