A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Zhibin Hu, Yankai Xia, Xuejiang Guo, Juncheng Dai, HongGang Li, Hongliang Hu, Yue Jiang, Feng Lu, Yibo Wu, Xiaoyu Yang, Huizhang Li, Bing Yao, Chuncheng Lu, Chenliang Xiong, Zheng Li, Yaoting Gui, Jiayin Liu, Zuomin Zhou, Hongbing Shen, Xinru Wang, Jiahao Sha

Nature Genetics, 2011. DOI 10.1038/ng.1040

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2013.

Replications

Replication Study and Meta-Analysis of Human Nonobstructive Azoospermia in Japanese Populations1, Sato et al. (2013). Biology of Reproduction. Outcome recorded: mixed. n the meta-analysis, the combined per-allele odds ratios (ORs) for the four SNPs and their respective 95% confidence intervals (CIs) were as follows: rs12097821, OR = 1.10 (CI = 0.89–1.37); rs2477686, OR = 1.11 (CI = 0.87–1.43); rs10842262, OR = 1.11 (CI = 0.94–1.32); and rs6080550, OR = 0.96 (CI = 0.76–1.21). None of the SNPs was significantly associated with NOA (P > 0.05). However, three of four SNPs (rs12097821, rs2477686, and rs10842262) showed associations in the same… Read from abstract. View paper

Cite this record

Hu, Z., Xia, Y., Guo, X., Dai, J., Li, H., Hu, H., Jiang, Y., Lu, F., Wu, Y., Yang, X., Li, H., Yao, B., Lu, C., Xiong, C., Li, Z., Gui, Y., Liu, J., Zhou, Z., Shen, H., et al. (2011). A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nature Genetics, 44(2), 183–186. https://doi.org/10.1038/ng.1040

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