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Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

James Bentham, David L Morris, Deborah S Cunninghame Graham, Christopher L Pinder, Philip Tombleson, Timothy W Behrens, Javier Martín, Benjamin P Fairfax, Julian C Knight, Lingyan Chen, Joseph Replogle, Ann-Christine Syvänen, Lars Rönnblom, Robert R Graham, Joan E Wither, John D Rioux, Marta E Alarcón-Riquelme, Timothy J Vyse

Nature Genetics, 2015. DOI 10.1038/ng.3434

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed.

Replications

• Recapitulation of Candidate Systemic Lupus Erythematosus-Associated Variants in Koreans, Kwon et al. (2016). Outcome recorded: mixed. rs1801274 in FCGR2A was found to be significantly associated with SLE in Koreans (odds ratio, 1.26, 95% confidence interval, 1.06 to 1.50; p = 0.01 in allelic model). The other four SNPs did not show a significant association. View paper

Other studies in the atlas

• Recapitulation of Candidate Systemic Lupus Erythematosus-Associated Variants in Koreans
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• Measuring objectification through the Body Inversion Paradigm: Methodological issues
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• Focused written corrective feedback and linguistic target mastery: Conceptual replication…
• Asymmetric transcallosal conduction delay leads to finer bimanual coordination

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