Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study
Has this study been replicated?
The atlas records 2 replications of this study. Recorded outcomes: 1 successful, 1 mixed. The earliest on record is from 2008.
Replications
- Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis, Hoppenbrouwers et al. (2009). Journal of Human Genetics. Outcome recorded: successful.
Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E−124), IL7R (P=6E−09), IL2RA (P=1E−11), CD58 (P=4E−09) and CLEC16A (P=3E−12).
Outcome read from the abstract. View paper - Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians, Rubio et al. (2008). Genes & Immunity. Outcome recorded: mixed.
Of 16 SNPs that passed quality control filters, four, each corresponding to a different non-human leukocyte antigen (HLA) gene, were associated with disease susceptibility: KIAA0350 (rs6498169) P=0.001, IL2RA (rs2104286) P=0.033, RPL5 (rs6604026) P=0.041 and CD58 (rs12044852) P=0.042.
Outcome read from the abstract. View paper
Cite this record
Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study. (2007). New England Journal of Medicine, 357(9), 851–862. https://doi.org/10.1056/nejmoa073493
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