Risk Alleles for Multiple Sclerosis Identified by a Genomewide Study

New England Journal of Medicine, 2007. DOI 10.1056/nejmoa073493

Has this study been replicated?

The atlas records 2 replications of this study. Recorded outcomes: 1 successful, 1 mixed.

Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis, Hoppenbrouwers et al. (2009). Outcome recorded: successful. Of the 17 IMSGC SNPs, five SNPs showed genome-wide significant association with MS: HLA-DRA (P=8E−124), IL7R (P=6E−09), IL2RA (P=1E−11), CD58 (P=4E−09) and CLEC16A (P=3E−12). View paper
Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians, Rubio et al. (2008). Outcome recorded: mixed. Of 16 SNPs that passed quality control filters, four, each corresponding to a different non-human leukocyte antigen (HLA) gene, were associated with disease susceptibility: KIAA0350 (rs6498169) P=0.001, IL2RA (rs2104286) P=0.033, RPL5 (rs6604026) P=0.041 and CD58 (rs12044852) P=0.042. View paper