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E2-2 Protein and Fuchs's Corneal Dystrophy

Keith H. Baratz, Nirubol Tosakulwong, Euijung Ryu, William L. Brown, Kari Branham, Wei Chen, Khoa D. Tran, Katharina E. Schmid-Kubista, John R. Heckenlively, Anand Swaroop, Goncalo Abecasis, Kent R. Bailey, Albert O. Edwards

New England Journal of Medicine, 2010. DOI 10.1056/nejmoa1007064

Has this study been replicated?

The atlas records 2 replications of this study. Recorded outcomes: 2 successful.

Replications

• Replication of theTCF4Intronic Variant in Late-Onset Fuchs Corneal Dystrophy and Evidence of Independence from theFCD2Locus, Riazuddin et al. (2011). Outcome recorded: successful. "the first independent replication of rs613872 conferring risk of late-onset FCD." View paper
• Replication of TCF4 through Association and Linkage Studies in Late-Onset Fuchs Endothelial Corneal Dystrophy, Li et al. (2011). Outcome recorded: successful. We found significant association with rs613872, the target marker reported by Baratz et al.(2010), for all three genetic models (DOM: P = 9.33×10(-35); ADD: P = 7.48×10(-30); REC: P = 5.27×10(-6)). View paper

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