E2-2 Protein and Fuchs's Corneal Dystrophy
Has this study been replicated?
The atlas records 2 replications of this study. Recorded outcomes: 2 successful. The earliest on record is from 2011.
Replications
- Replication of theTCF4Intronic Variant in Late-Onset Fuchs Corneal Dystrophy and Evidence of Independence from theFCD2Locus, Riazuddin et al. (2011). Investigative Opthalmology & Visual Science. Outcome recorded: successful.
"the first independent replication of rs613872 conferring risk of late-onset FCD."
Outcome read from the abstract. View paper - Replication of TCF4 through Association and Linkage Studies in Late-Onset Fuchs Endothelial Corneal Dystrophy, Li et al. (2011). PLoS ONE. Outcome recorded: successful.
We found significant association with rs613872, the target marker reported by Baratz et al.(2010), for all three genetic models (DOM: P = 9.33×10(-35); ADD: P = 7.48×10(-30); REC: P = 5.27×10(-6)).
Outcome read from the abstract. View paper
Cite this record
Baratz, K. H., Tosakulwong, N., Ryu, E., Brown, W. L., Branham, K., Chen, W., Tran, K. D., Schmid-Kubista, K. E., Heckenlively, J. R., Swaroop, A., Abecasis, G., Bailey, K. R., & Edwards, A. O. (2010). E2-2 Protein and Fuchs's Corneal Dystrophy. New England Journal of Medicine, 363(11), 1016–1024. https://doi.org/10.1056/nejmoa1007064
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