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Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

Stephane Jamain, Konstantin Radyushkin, Kurt Hammerschmidt, Sylvie Granon, Susann Boretius, Frederique Varoqueaux, Nelina Ramanantsoa, Jorge Gallego, Anja Ronnenberg, Dorina Winter, Jens Frahm, Julia Fischer, Thomas Bourgeron, Hannelore Ehrenreich, Nils Brose

Proceedings of the National Academy of Sciences, 2008. DOI 10.1073/pnas.0711555105

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 failed.

Replications

• Absence of deficits in social behaviors and ultrasonic vocalizations in later generations of mice lacking neuroligin4, Ey et al. (2012). Outcome recorded: failed. Our findings indicate an absence of autism‐relevant behavioral phenotypes in subsequent generations of Nlgn4 mice tested at two locations. View paper

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