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Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Charles Y. Lin, Jakob Lovén, Peter B. Rahl, Ronald M. Paranal, Christopher B. Burge, James E. Bradner, Tong Ihn Lee, Richard A. Young

Cell, 2012. DOI 10.1016/j.cell.2012.08.026

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed.

Replications

• Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc, Lewis et al. (2018). Outcome recorded: mixed. Transcripts from genes that were silent before c-Myc induction also increased in expression following c-Myc overexpression, while the original study concluded elevated c-Myc had no effect on silent genes View paper

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