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The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

Can Liu, Kevin Kelnar, Bigang Liu, Xin Chen, Tammy Calhoun-Davis, Hangwen Li, Lubna Patrawala, Hong Yan, Collene Jeter, Sofia Honorio, Jason F Wiggins, Andreas G Bader, Randy Fagin, David Brown, Dean G Tang

Nature Medicine, 2011. DOI 10.1038/nm.2284

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 failed.

Replications

• Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44, Yan et al. (2019). Outcome recorded: failed. we did not observe changes in tumor growth or CD44 expression; however, unexpectedly miR-34a expression was lost in vivo. View paper

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