The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Stephen B. Willingham, Jens-Peter Volkmer, Andrew J. Gentles, Debashis Sahoo, Piero Dalerba, Siddhartha S. Mitra, Jian Wang, Humberto Contreras-Trujillo, Robin Martin, Justin D. Cohen, Patricia Lovelace, Ferenc A. Scheeren, Mark P. Chao, Kipp Weiskopf, Chad Tang, Anne Kathrin Volkmer, Tejaswitha J. Naik, Theresa A. Storm, Adriane R. Mosley, Badreddin Edris, Seraina M. Schmid, Chris K. Sun, Mei-Sze Chua, Oihana Murillo, Pradeep Rajendran, Adriel C. Cha, Robert K. Chin, Dongkyoon Kim, Maddalena Adorno, Tal Raveh, Diane Tseng, Siddhartha Jaiswal, Per Øyvind Enger, Gary K. Steinberg, Gordon Li, Samuel K. So, Ravindra Majeti, Griffith R. Harsh, Matt van de Rijn, Nelson N. H. Teng, John B. Sunwoo, Ash A. Alizadeh, Michael F. Clarke, Irving L. Weissman

Proceedings of the National Academy of Sciences, 2012. DOI 10.1073/pnas.1121623109

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 mixed. The earliest on record is from 2017.

Replications

Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors, Horrigan (2017). eLife. Outcome recorded: mixed. "We found that treatment of immune competent mice bearing orthotopic breast tumors with anti-mouse CD47 antibodies resulted in short-term anemia compared to controls, consistent with the previously described function of CD47 in normal phagocytosis of aging red blood cells and results reported in the original study (Table S4; Willingham et al., 2012). The weight of tumors after 30 days administration of anti-CD47 antibodies or IgG isotype control were not found to be… Outcome read from the abstract. View paper

Cite this record

Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R., Cohen, J. D., Lovelace, P., Scheeren, F. A., Chao, M. P., Weiskopf, K., Tang, C., Volkmer, A. K., Naik, T. J., Storm, T. A., Mosley, A. R., … Weissman, I. L. (2012). The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proceedings of the National Academy of Sciences, 109(17), 6662–6667. https://doi.org/10.1073/pnas.1121623109

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