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Evidence for lifespan extension and delayed age–related biomarkers in insulin receptor substrate 1 null mice

Colin Selman, Steven Lingard, Agharul I. Choudhury, Rachel L. Batterham, Marc Claret, Melanie Clements, Faruk Ramadani, Klaus Okkenhaug, Eugene Schuster, Eric Blanc, Matthew D. Piper, Hind Al‐Qassab, John R. Speakman, Danielle Carmignac, Iain C. A. Robinson, Janet M. Thornton, David Gems, Linda Partridge, Dominic J. Withers

The FASEB Journal, 2007. DOI 10.1096/fj.07-9261com

Has this study been replicated?

The atlas records 1 replication of this study. Recorded outcomes: 1 successful.

Replications

• Replication of Extended Lifespan Phenotype in Mice with Deletion of Insulin Receptor Substrate 1, Selman et al. (2011). Outcome recorded: successful. we show that, consistent with our previous finding, global deletion of Irs1 significantly extends lifespan in female mice. In addition, an augmented and completed study demonstrates lifespan extension in male Irs1 null mice. View paper

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